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KMID : 0385520150280010072
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Analytical Science & Technology
2015 Volume.28 No. 1 p.72 ~ p.77
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Effect of Angelica gigas extract powder on progress of osteoarthritis induced by monosodium iodoacetate in rats
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Kwon Jin-Hwan
Han Min-Seok
Lee Bu-Min
Lee Yong-Moon
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Abstract
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To study the efficacy of extract powder of Angelica gigas in preventing and treating degeneration of the articular cartilage in rats with monosodium iodoacetate (MIA)-induced osteoarthritis, A total of 30 six-week-old Sprague-Dawley rats were randomly divided into normal control group, untreated group and Angelica gigas treated group, with 10 rats in each group. During the treatment period, body weight were measured in each four days interval from starting date. The rat were sacrificed at the end of 3rd week after daily administration of Angelica gigas and then rat tibia articular cartilage was removed. In articular cartilages, glycosaminoglycan (GAG) amount increased by MIA treatment were reduced while proteoglycan (PG) amount decreased by MIA treatment were fairly recovered by Angelica gigas treatment, respectively. The content of TNF-a was also slightly reduced sections of the cartilage were stained with safranin-0 were also partially recovered by Angelica gigas treatment. By HPLC analysis, the content of main compounds decursin and decursinol angelate was analyzed as 10.5 ± 0.2% of total extracts.
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KEYWORD
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Angelica gigas, monosodium iodoacetate, osteoarthritis, glycosaminoglycan, proteoglycan,
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